Preoperative serum levels of lipocalin-2 and matrix metalloproteinase-9 (MMP-9) are associated with prognosis of breast cancer
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Serum levels of matrix metalloproteinase-9 predict lymph node metastasis in breast cancer patients.
Matrix metalloproteinases (MMPs) are proteolytic enzymes that play important roles in cancer progression and metastasis. Although serum MMP expression is known to correlate with the primary lesion of breast cancer, there has yet to be a study regarding the correlation between serum MMP expression and metastatic lesions, particularly lymph nodes. The present study evaluated the correlation of se...
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متن کاملThe relationship between MMP-2 and MMP-9 expression levels with breast cancer incidence and prognosis
The relationship between the expression levels of matrix metalloproteinase-2 (MMP-2) and MMP-9 and breast cancer prognosis was studied. Two breast cancer cell lines (MDA-MB-231 and MCF-7) and one human normal breast cell line (HS578Bst) were investigated. Fluorescence real-time reverse transcription-polymerase chain reaction (RT-PCR) and western blotting were used to detect cellular mRNA and pr...
متن کاملPreoperative serum levels of matrix metalloproteinase-2 (MMP-2) and survival of breast cancer among Korean women.
BACKGROUND Matrix metalloproteinase-2 (MMP-2) has been thought of as a predictor of recurrence or metastasis risk or prognostic markers in cancer. We evaluated whether preoperative serum levels of MMP-2 work as a prognostic biomarker in breast cancer prognosis. METHODS Preoperative serum levels of MMP-2 were measured with ELISA in 303 patients with histologically confirmed breast cancer. The ...
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تاریخ انتشار 2012